Investigation of the NF-κB, TRAF1, and TRAF2 Relative Gene Expressions in a Population of Iranian Patients with Oral Squamous Cell Carcinoma: A Case-Control Study

Document Type : Original Article

Authors

1 Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran

2 Deptartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

3 Department of Maxillofacial Surgery, Dental school, Zahedan University of Medical School, Zahedan, Iran

4 Department of Endodontics, Faculty of Dentistry, Oral and Dental Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

Abstract

Objective: Oral squamous cell carcinoma (OSCC) is a frequently prevalent subtype of oral cancer with late detection and diagnosis and an elevated mortality rate. It can be triggered via genetic and environmental factors, creating several patient difficulties. The main concern is to comprehend the interaction between variables to explain the regulation of oral cancer, as well as the process of its occurrence. Nuclear factor kappa B (NF-κB) belongs to a class of induced transcription factors, controlling various genes responsible for several aspects of inflammation and immunological processes. It is regulated through diverse genes, such as TNF receptor-associated factor 1 (TRAF1) and TNF receptor-associated factor 2 (TRAF2). The disruption of this pathway may contribute to various health problems.
Materials and Methods: Eighteen paraffin-embedded oral cancer tissues and 18 oral mucosae tissues were applied to evaluate gene expression profiles via quantitative real-time PCR (qRT-PCR) in a population in Southeast Iran.
Results: NF-κB (95% CI = -0.804 to -0.222, p-value = 0.001), TRAF1 (95% CI = -3.201 to -1.018, p-value < 0.0001), and TRAF2 (95% CI = -1.802 to -0.86, p-value = 0.019) gene expressions were revealed a strong correlation with OSCC.
Conclusion: Our findings revealed that the increased gene expression levels of NF-κB, TRAF1, and TRAF2 are closely linked to clinical manifestations in OSCC.

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Journal of Epigenetics
Volume 4, Issue 1 - Serial Number 1
September 2023
Pages 7-1

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History

  • Receive Date: 25 November 2022
  • Revise Date: 21 February 2023
  • Accept Date: 10 July 2023

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